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For each of the ATC classes selected, a list of new medicinal products was extracted from the database, when feasible, choosing the first-in-class and if possible, excluding the medicines with more than one indication in the original registration

## Efficacy: Weight Loss Results Comparison ### Phase 2 and Phase 3 Data for Orforglipron The orforglipron Phase 2 trial, published in *Nature Medicine*, randomized 272 adults with obesity to orforglipron (12 mg, 24 mg, 36 mg, or 48 mg daily) or placebo over 36 weeks

They have not yet been approved for this purpose

Benefits of Oral Semaglutide You dont need needles: For people with needle phobia (or who simply dont like getting pricked), this can create a significant advantage

Rotating injection sites helps minimize these reactions