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Metformin prevents mandibular bone loss in a mouse model of accelerated aging by correcting dysregulated AMPK-mTOR signaling and osteoclast differentiation

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When Wnt signaling is activated, -catenin accumulates in the cytoplasm and enters the nucleus, where it binds to T-cell factor (TCF)/lymphoid enhancer factor (LEF) transcription factors and promotes the expression of osteogenesis-related genes, thereby increasing bone formation (53)