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The microbial metabolites related to intestinal sensory, motor and secretory functions including secondary bile acids, short-chain fatty acids and polyunsaturated fatty acids, may also contribute to abdominal pain in in FC and IBS-C, but the mechanisms are still unclear [41, 58, 59]

In Se deficiency, GPx activity decreases, degradation of H2O2 is reduced, thyroid cells are less resistant to oxidative stress, apoptosis and cell death occur ( 3 Se deficiency is one of the risk factors for many thyroid diseases 3.1 Se and Graves disease The main clinical manifestation of Graves disease (GD), also known as toxic diffuse goiter, is thyrotoxicosis caused by excessive production of thyroid hormones

Lab monitoring is individualized

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It is produced by virtually every cell and is essential for protecting DNA, proteins, and cellular structures from oxidative damage