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Fasting periods or times between meals typically intensify cold feelings due to reduced thermogenesis (the heat produced through digestion)
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Thus, at any one time the local levels of active estrogens depend on finely balanced biosynthetic, metabolic and deactivation pathways
Diarrhoea is also prevalent with Wegovy, with around 30% of participants experiencing this at least once
Systemic vs localized response mechanisms
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