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Nature 649 , 487495 (2026)
This reduction risk was consistent across both kidney-specific and cardiovascular death outcomes
That said, estrogen has well-documented effects on insulin sensitivity, fat distribution, and metabolic risk, which makes it reasonable to ask whether hormone status modifies response to anti-obesity pharmacotherapy
During your first two weeks on semaglutide, you may experience less nausea than you had on tirzepatide, particularly if GI side effects were your reason for switching
Weight and lipid effects tend to be modest and contingent on baseline adiposity and lifestyle co-interventions (159)
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