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The absence of or minimized -arrestin recruitment leads to reduced receptor internalization and potentially prolonged pharmacological activity

Focal hemosiderin deposits and -amyloid load in the ADNI cohort

Mann JFE, Buse JB, Idorn T, Leiter LA, Pratley RE, Rasmussen S, Vilsbll T, Wolthers B, Perkovic V

However, because both ultimately increase insulin activity (through different pathways), the risk of hypoglycaemia is elevated when they are used together, necessitating careful dose titration and patient education

These events should not be presented as directly demonstrated AOD9604 mechanisms unless the relevant endpoint was measured in an AOD9604-specific experiment