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Yes, B12 supplementation is appropriate if deficiency is confirmed, and the MHRA recommends monitoring B12 levels in people on long-term metformin

Because absorption is limited, raising serum B12 with pills is a gradual, cumulative process that can take weeks or months of consistent daily use

In vivo recordings : chronic electrodes in CA1 to measure theta/gamma oscillations, sharp-wave-ripples (mnemonic replay)

Interim data from REDEFINE 1 have suggested meaningful body weight reductions in adults with obesity over 68 weeks, comparing favourably with semaglutide alone

The drug creates a positive feedback loop where weight loss improves the metabolic environment, which makes further metabolic normalization easier