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The initial pivotal studies that led to the first wave of GLP-1 RAs demonstrated that they work in several ways, including stimulating insulin release, slowing digestion, reducing appetite, and inhibiting glucagon release
To date, available experimental evidence supports the paradigm that every weight loss achieved through dieting may be followed by diabetes remission in a proportionally large number of patients, while it is less clear whether qualitative aspects of the diet are equally influential
The compound did not advance to Phase 3 because the efficacy was insufficient for drug approval
Common Side Effects The most common side effects are nausea, bloating, vomiting, diarrhea, constipation, and early fullness
Can Ozempic affect kidney function
