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Daniel Drucker's laboratory later characterized the molecular control of proglucagon expression and the broader physiology of GLP-1 signaling [4]
This recommendation is based on animal studies in which semaglutide was associated with harmful effects on animal pregnancies and fetuses, such as fetal abnormalities, pregnancy losses, and growth changes in rats, rabbits, and monkeys
J Clin Gastroenterol 2010
Until larger studies confirm these effects, Ozempic remains approved only for type 2 diabetes and, off-label, for weight management not for treating alcohol dependence
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