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The limited human evidence includes: A randomised double-blind placebo-controlled Phase 2 enema trial in ulcerative colitis with 53 participants, published only as a meeting abstract
Laboratory studies using chondrocyte cultures and animal models have investigated how the peptide influences pathways involved in extracellular matrix regulation and tissue repair [4]
Intramuscular B12 injections bypass the digestive tract entirely, ensuring full bioavailability where oral supplementation may be insufficient or ineffective
Evidence Full-length TB-4 has human clinical research across corneal, cardiac, and wound-repair programs, including clean Phase 1 safety data, plus dermal wound-healing models
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