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Science 353(6307):1514

In addition, there is evidence that pioglitazone reduces the risk of MI and acute coronary syndrome in patients with cardiovascular diseases (CVD) and patients with type 2 diabetes who had previous myocardial infarction [220,221,222]

And honestly, most research failures related to peptides aren't due to a lack of knowledge, but to small, avoidable lapses in protocol