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Because only one company manufactures the branded version, supply chain issues have frequently led to nationwide shortages

But just so you know were talking about the same thing

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That comparison is from the studied FDA-approved products under trial conditions - it's relevant context for understanding why tirzepatide's higher efficacy average might justify its slightly higher price point, but it doesn't predict the gap in any individual patient's results

While our methods focused on comparing GLP-1RAs to metformin or placebo, we acknowledge the possibility that additional background interventions may have been employed across some studies