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Side effects such as nausea, reflux, cramping, and constipation are common side effects that may limit use, too

So, similar to the hormone, these drugs tell the pancreas to release more insulin when blood sugar rises (typically during and after eating)

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DOI: 10.1111/bjd.13598 MC1R Selectivity and Receptor Pharmacology Comparative receptor binding studies have confirmed MT-1s preferential activity at MC1R versus the broader receptor profile of MT-2, establishing it as the reference compound for isolated MC1R pathway research