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Unlike single-pathway compounds, retatrutide simultaneously activates three distinct receptor systems: GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors [3]

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However, many reported GSH-responsive systems demonstrate incomplete drug release under physiological intracellular GSH levels (110 mM), suggesting an overestimation of redox sensitivity in vitro

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