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The two medications work through separate pathways, but GLP-1 receptor activation in the hypothalamus directly inhibits GH-releasing hormone (GHRH) signaling, creating a counterbalance effect
Ferri, K.F
Meneguello, MA
The medication is available in 3 mg, 7 mg, and 14 mg tablets, with dosing typically initiated at the lowest strength and titrated upward based on glycemic response and tolerability
As of the time of writing, both agents remain in clinical development and have not received a marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA)
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