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186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria
PMCID: PMC10385428
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Similarly, exposure to cadmium increases the levels of GCL mRNA in Brassica juncea (Indian mustard) and activates transcription of both GCL and GS in Arabidopsis thaliana (thale cress
