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Safety Concerns When Combining Phentermine With GLP-1 Agonists The FDA and major medical societies have not approved concurrent use of phentermine with semaglutide or other GLP-1 agonists, and no rigorous clinical trials have evaluated this combination in humans

JAMA, 315 (22), 24242434

GLP-1R (Glucagon-Like Peptide-1 Receptor) GLP-1 is an incretin hormone secreted by L-cells in the small intestine in response to food intake

Chin JN Drugs 32(5):547552 Zhengzhi W, Jiguo W, Xiaoli Z, Meiqun C, Anmin WU (2011) Preliminary studies on diagnostic cast of peptic ulcer based on saliva proteome and bioinformatics

Do Oral GLP-1 Drugs Work as Well as Injectables