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Importantly, weight-matching through calorie restriction or pair-feeding to lean control body weights does not restore leptin signaling in these other BBS models, resulting in persistent hyperleptinemia and increased fat mass (24, 26)
Pharmacological inhibition of CPT1A results in impaired cancer cell proliferation in acute myeloid leukemia and intensive cytotoxicity in Burkitts lymphoma 23,32
When used appropriately, GLP-1 analogs have been shown to be safe
Additionally, traditional Chinese medicines and their bioactive components have shown promising anti-ferroptotic effects through multi-target and multi-pathway mechanisms (10)
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