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Orforglipron also is more likely to increase heart rate (by about 4 beats per minute)

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"Tyrosine-rich acidic matrix protein (TRAMP) is a tyrosine-sulphated and widely distributed protein of the extracellular matrix"

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Patients with diabetes have been taking older versions of GLP-1 agonists for almost 20 years

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Zhang S, Tomata Y, Sugiyama K, Sugawara Y, Tsuji I

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Weight loss procedures such as calorie restriction and metabolic/bariatric surgery are known to affect bone health because they elevate bone turnover markers (BTMs) and reduce bone mineral density (BMD) [7,8,9]

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