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Discontinuation in trials: retatrutide trial discontinuation due to adverse events was 6-10% across the higher-dose arms meaningful but lower than the dose-related side-effect profile would suggest, which indicates most participants tolerated the protocol

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Incubation with 1 M L3740 for 48 h has increased GLP-1 secretion and the number of L-cells in human and mouse intestinal organoids through GLP-1R signaling and serotonin signaling