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City, which was founded by former Alnylam Pharmaceuticals CEO John Maraganore, is developing what they hope will be the next generation of gene-silencing drugs

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Hypothalamic tanycytes are glial cells located along the walls and floor of the third ventricle, which are known to play neuroendocrine roles such as detecting and transporting nutrients and hormones like insulin and GLP-1, as well as regulating neuronal activity [60-62]

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When drug levels spike above the expected range, the body sometimes responds with a compensatory rebound

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