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Safety Profile Across Patient Populations and Risk Factors Safety outcomes vary based on individual factors: baseline B12 status, kidney function, history of injection reactions, and concurrent medications

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The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)

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