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The introduction of the R17 Cagri- E14 Cagri intra-peptide ionic lock energetically favours the formation of a predominant bypass conformation at the CTR, which, together with the P37 substitution and the effects induced by the N-terminal acylation, likely underlies its improved potency over rAmy at this receptor

Stick around and Ill walk through how the two differ at the receptor level, what the clinical-trial data show on weight, blood sugar, and side effects, how they stack up on cholesterol and liver fat, and what that missing head-to-head really means

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