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In line with current ADA/EASD guidance, GLP-1 RAs may be prioritized for people with T2DM who have established ASCVD or are at high renal risk

The condition primarily manifests as megaloblastic anemia with recurrent diarrhea, mouth ulcers, recurrent infections, anemia and loss of appetite, which typically occur in the first months of life

In a recent study in which different biochemical assays in patient fibroblasts were correlated to clinical severity, residual oleate fatty acid oxidation flux turned out to be strongly correlated with clinical severity for VLCAD deficiency

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one of these cerebella also showed an almost complete loss of Purkinje cells from the Purkinje cell layer, as well as a marked loss of granular cells