The post says human clinical data remain sparse, that most evidence comes from case reports and small observational studies rather than randomized controlled trials, and that the signaling claim comes from animal work
Category 2 preparations, made in ISO-classified cleanrooms with stricter environmental controls, can receive longer BUDs of up to 60 days refrigerated or even longer with stability testing data

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Dorsey-Trevio EG, Gonzlez-Gonzlez JG, Alvarez-Villalobos N, et al