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The two compounds don't directly interact in the body
(Source: Truveta, May 2026) Important limitation from the researchers themselves: This analysis covered only semaglutide and tirzepatide, and did not account for other common PCOS treatments such as metformin, combined oral contraceptives, or anti-androgen therapies
For the complete breakdown of all trials, see our clinical results guide
Additionally, the impact of dietary phytoestrogensplant-derived compounds with estrogenic activityhas been debated [88]
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