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B12 is water-soluble, so your body uses what it needs, stores a small amount in the liver, and passes most of the excess in urine

Hematologic and biochemical monitoring throughout the trials revealed no concerning patterns in blood counts, liver function tests, kidney function markers, or other laboratory parameters

Clinically meaningful responses in insulin-resistant patients typically include a reduction in fasting insulin of 20-40% and an improvement in HOMA-IR within 8-12 weeks at therapeutic doses, though individual variability is wide [1]

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The Typical Starting Dose of 1000 mcg (1 mg) The usual first dose for adults is 1000 mcg (1 mg) of vitamin B12