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As a nutritional therapist, I am frequently asked about the efficacy of GLP-1 for binge eating , specifically how these medications interact with the neurodivergent brain to stop the cycle of restriction and reward

Learn who benefits most, what results to expect, how long they last, and when testing may be helpful

Growth hormone peptides (CJC-1295, ipamorelin, sermorelin) are particularly relevant for this population because endogenous GH production declines approximately 14% per decade after age 30

Semaglutide works by attaching to GLP-1 receptors in the body

Further electrophysiological study showed that, opposite to the effects on arcuate POMC neurons, GLP-1 hyperpolarizes arcuate NPY neurons indirectly via increased GABA A receptor-mediated neurotransmission of local GABAergic interneurons (Secher et al., 2014