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Smaller populations are more vulnerable to genetic drift, inbreeding, and disrupted adaptive responses which eventually can affect survival and reproduction success

For immunoregulation, butyrate activates GPR41/43/109A receptors to promote Treg differentiation and, as a histone deacetylase inhibitor, remodels chromatin structure, upregulates anti-fibrotic gene expression, and directly inhibits TGF- signaling to reduce COL1A1 expression at both mRNA and protein levels (Wang et al., 2022)

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Growth factors and cytokines that modulate the local immune environment and recruit endogenous repair cells

Source NIH / PMC10937548 of women report feeling dismissed when seeking medical help