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Increases in oxidative stress may shift homocysteine metabolism towards trans-sulfuration to increase hepatic production of reduced glutathione
The ADRs of interest include suicidal ideation, self-injurious ideation, suicidal behaviors, and self-injurious behaviors (see Additional file 1: Table S1 for a detailed list), which are homogenously attributed to a high-level group term (HLGT) named suicidal and self-injurious behavior by MedDRA (version 26.0)
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Michelle Brown 2 , Bonita Basnyat 2 , Jennifer Dine 2 1 Ionis Pharmaceuticals, Carlsbad, California, USA, 2 RTI Health Solutions, Research Triangle Park, North Carolina, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :2032 Aims Severe hypertriglyceridemia (sHTG) and familial chylomicronemia syndrome (FCS) are characterized by high triglyceride levels associated with negative impacts on physical, emotional, social, and cognitive function
Rice and beans, hummus and whole grain pita, and nut butter on whole grain bread all provide complete amino acid profiles
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