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Oxidative stress, inflammation, and a decline in mitochondrial function are major contributors to this process
Temperature excursions compromise potency
Gingivectomy, laser therapy, and cryosurgery can all effectively remove oral pigmentation
Vekovischeva OY, Zamanillo D, Echenko O, Seppala T, Uusi-Oukari M, Honkanen A et al (2001)
Generally, adverse effects were benign in all trials
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