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There was a significant rise in the number of late spermatids, as well as the areas of the lobule and lumen, in fish treated with 30 g of IPA, compared to the control group

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Low incidences of seizures have been reported with oral doses in individuals with or without pre-existing seizure disorders.

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Lipoic acid is covalently bound to certain proteins, which function as part of essential mitochondrial multienzyme complexes involved in energy and amino acid metabolism (see Biological Activities)