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A team of researchers developed a nanostructure-based GLP-1R agonist capable of crossing the BBB that significantly attenuated neuroinflammation and memory loss in an A peptide-induced mouse model of AD by inhibiting the inflammatory responses of microglia and astrocytes (Zhao et al., 2022)
doi: 10.1126/scitranslmed.abb3774 57 CopinJ.-C.GascheY.ChanP
and the National Research, Development and Innovation Fund of the Ministry of Culture and Innovation, under the National Laboratories Program (National Tumor Biology Laboratory, 20222.1.1-NL-2022-00010) and the Hungarian Thematic Excellence Program (project TKP2021-EGA-44) to P.N
Consistent with the literature, VEGF expression was linked with T4 expression, such that in T4-overexpressing mice, VEGF expression was increased and, in T4 KO mice, VEGF expression was reduced
Cycling protocols further reduce accumulation concerns by providing regular breaks
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