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Sun and colleagues reported cryo-electron microscopy structures of tirzepatide bound to both the GIP receptor and the GLP-1 receptor in the Proceedings of the National Academy of Sciences in 2022

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Recent data have indicated that such an effect may depend on the influence on metabolic processes because in chronic unpredictable mild stress (CUMS) in mice, the decreased GLP-1 level in the hippocampus was increased with metformin treatment [46]

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