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Patients with pancreatic insufficiency may have reduced cobalamin absorption (because pancreatic enzymes normally assist with the displacement of salivary haptocorrin binding protein by intrinsic factor), although such patients rarely become cobalamin deficient

Vitamin B-12 is naturally available in meats, but people who do not eat meat, such as vegans, can obtain vitamin B-12 in supplement form

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The zero withdrawal rate in AOD-9604 trials suggests excellent practical tolerability that extends beyond merely counting adverse events to assessing their real impact on treatment continuation

Researchers should understand both the available data and its limitations