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& Yannick, F

It must be noted that the osmotic pressure adjustment in the control group should be made by adding mannitol or another suitable organic solute to the medium, because these are biocompatible and non-toxic, making it a suitable choice for adjusting osmotic pressure without interfering with the biological processes under study [183]

Br J Pharmacol (2011) 164(5):141020

Valproate is therefore contraindicated for prophylaxis of migraine headaches in pregnant women and in women of childbearing potential who are not using effective contraception [seeContraindications (4)]

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