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The ratio of GSH to GSSG decreases with exposure to oxidative stress (2, 3), and an imbalance in the GSH/GSSG ratio has been documented in a variety of disorders, such as cancer, neurodegenerative diseases, and viral infections (4)
Importantly, overexpression of c-Met in glioblastoma cells diminished the inhibitory effects of AC on cell growth and EMT marker expression, confirming that c-Met is a critical target of ACs action
The results were derived from two independent experiments containing three transfection replicates
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After the microneedle is inserted into the psoriatic skin, the needle tip separates from the base, and MTX is rapidly released from the swollen gel pores, promptly inhibiting keratinocyte proliferation, while EGCG breaks the bond in response to the high ROS environment in the skin and releases in an intelligent and controlled manner, effectively inhibiting the NF-B inflammatory pathway for a long time (Zhao Y
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