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In cardiac cells, the physical proximity between mitochondria and the sarcoplasmic reticulum (SR, a specific type of ER in heart and skeletal muscle cells) allows the exchange of Ca 2+ in local microdomains, providing rapid Ca 2+ buffering

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J Agric Food Chem 68:63906394 Khonde PL, Jardine A (2015) Improved synthesis of the super antioxidant, ergothioneine, and its biosynthetic pathway intermediates