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They found that although many regions of the brain have GLP-1 receptors, when the mice were dosed with the GLP-1R agonist semaglutide, the semaglutide ended up on only a fraction of the mouse brains GLP-1 receptors, mainly in the hypothalamus, brainstem, and septum

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This dual-action approach enhances appetite suppression, improves insulin sensitivity, and further slows gastric emptying

3ac), we next assessed in nave and weight-matched DIO mice whether the acute glycaemic benefits prevail even at single subcutaneous (s.c.) doses subthreshold for the GLP-1RA to improve glucose metabolism