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It allows for more accurate study design, as you can be more confident in the actual amount of the compound interacting with target tissues
& Fontana, L
FIGURE 1 2.2.1 Dysregulation of renal iron homeostasis DKD is accompanied by serious disorders of iron metabolism and redox balance, making renal cells highly susceptible to ferroptosis
The GRADE approach assessed the quality of the evidence for each outcome across five domains: risk of bias, inconsistency, indirectness, imprecision and publication bias
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