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In addition, increasing STAT3 from activated JAK/STAT signaling pathway might be involved in the apoptosis of cell through PTEN, which inhibits Akt cascade, resulting in exacerbated hyperglycemia 136 (Fig

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Furthermore, utilizing a nanodecoy with enriched ACE2 to neutralize SARS-CoV-2 and trigger the phagocytic clearance of the virus is another effective strategy for the prophylaxis and therapeutic use of COVID-19 52,53