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Emerging evidence suggests that GLP-1 receptor agonists can suppress dopamine signaling in reward circuits, effectively lowering the volume on cravings ( PMC , 2024)
Both GIP and GLP-1 receptors exist in brain regions controlling appetite and reward, which is why tirzepatide reduces food cravings and not just physical hunger
Patients should be aware that severe, persistent abdominal pain with vomiting could indicate pancreatitis, a rare but serious adverse effect of GLP-1 medications that requires immediate medical attention
Together with Derek Holdsworth, another gastroenterologist trainee, and Desmond Turner, a biochemist, McIntyre decided to revisit La Barre's hypothesis that the duodenum encouraged the pancreas to produce insulin by releasing incretin
