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Recent reviews have comprehensively addressed emerging trends in pulmonary delivery of biopharmaceuticals, including novel formulation strategies and advances in devices (Onoue et al., 2022)

These observations have contributed to ongoing research interest in the compounds potential interactions with vascular endothelial growth factor pathways

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This receptor-independence distinguishes MGF from mature IGF-1 at a fundamental pharmacological level and remains the primary mechanistic framework for PEG-MGF research design