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French RCT The EFFET Trial (Renard et al., 2020) A 12-week placebo-controlled pilot trial with 19 children found that low-dose leucovorin (5 mg twice daily) significantly improved core autism symptoms [6]
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Therefore, noting the lack of spontaneous oxidation of free GSH between the two EDTA-treated samples stored at 80 o C, this result also suggests that the differences in GSH between the heparinized plasma (Preparation Condition 1) and deproteinized EDTA-treated plasma (Preparation Condition 2) are due to spontaneous oxidation of free GSH occurring in the heparinized plasma prior to the deproteinization process
Curr Drug Abuse Rev
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