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NAD+ accepts a hydride ion to form NADH
Your hypothalamic appetite centers must recalibrate their signaling thresholds
Insufficient leptin signaling in the hypothalamus, which is caused by either decreased availability of leptin for transport to the hypothalamus (in the case of leptinopenia), or restricted leptin entry across the BBB (imposed by hyperleptinemia in obese subjects), is primarily responsible for inducing hyperglycemia and hyperinsulinemia
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