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Cortisol is catabolic and lipolysis-blunting in the context of chronic elevation

Pulsatile GH release is more effective for metabolic regulation, tissue repair, and overall hormonal balance than the flat, supraphysiological doses often seen with synthetic GH

Kern A, Albarran-Zeckler R, Walsh HE, et al

337 Mice that specifically knock out the Nampt gene of adipocytes have serious insulin resistance, which is manifested by an increase in plasma free fatty acid content and a decrease in plasma content of the main insulin-sensitive adipokine, adiponectin

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