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The SMILES trial used a modified Mediterranean diet built on these foundations and found that around a third of participants achieved remission from major depression after 12 weeks

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In addition, a clinical study on the effects of calorie restriction and semaglutide on body weight, body composition, and metabolic parameters in patients with type 2 diabetes found that calorie restriction had a better short-term weight-loss effect than semaglutide, and the combination of the two had a better effect on improving islet -cell function [22]