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doi: 10.1038/s41580-021-00418-x 125 JainS

Histologically, melatonin did not fully prevent immune cell accumulation in the lung parenchyma when Luzindole was present, however, the extent of infiltration remained markedly reduced compared with IL-33 alone ( Figures 2D, E )

But the skepticism is actually very reasonable

(2018) MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A, Cancer Sci

It has also been observed that ME/CFS shares a number of SNPs in HLA, IFN-, 5-HT, and NR3C1 genes with other disease-related fatigues (90)