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Nature (2016) 5347606:2137

What's New: August 2026 Update TRIUMPH-2 confirmed (July 23, 2026): Obesity + type 2 diabetes trial, 1,152 patients up to 20.8% weight loss and up to 1.6 percentage points HbA1c reduction at 80 weeks TRIUMPH-3 confirmed (July 23, 2026): Obesity + established cardiovascular disease trial, 1,949 patients up to 22.6% weight loss at 80 weeks, plus significant improvements in triglycerides, blood pressure, and inflammatory markers All four core TRIUMPH trials are now complete TRIUMPH-1, TRIUMPH-2, TRIUMPH-3, and TRIUMPH-4 have all reported positive topline results TRIUMPH-4 confirmed: 28.7% weight loss at 68 weeks in 445 participants topline results announced December 2025 TRIUMPH-1 confirmed (May 21, 2026): 28.3% average weight loss at 80 weeks in 2,339 patients the pivotal general obesity trial met all primary and key secondary endpoints TRIUMPH-1 extension: In a prespecified 104-week extension, patients with BMI 35 reached 30.3% average weight loss no plateau observed TRANSCEND-T2D-1 confirmed (topline March 2026, published June 2026): First dedicated Phase 3 diabetes trial -2.0% HbA1c and 16.8% weight loss in 537 type 2 diabetes patients OSA data confirmed (ADA June 6, 2026): TRIUMPH-1's nested sleep apnea substudy showed 60.6% AHI reduction from a severe-OSA baseline of 58.6 events/hour Filing timeline updated: Eli Lilly will submit a Biologics License Application (BLA) not an NDA, since retatrutide is a biologic now expected Q1 2027 (shifted from the previously estimated Q4 2026) Efficacy Summary Across All Completed Trials Phase 2: The Foundation (2023) The Phase 2 trial, published in the New England Journal of Medicine in June 2023, evaluated retatrutide in 338 adults with obesity (BMI 30) or overweight (BMI 27) with weight-related comorbidities

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Wang X, Martindale JL, Liu Y, HolbrookNJ

The meta-analysis data specifically highlighted that cagrilintide can be considered a promising therapeutic option for weight loss in individuals who may not tolerate GLP-1 receptor agonists or have a lower tolerance for nausea and vomiting