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Clinical trials have shown that people taking GLP-1 medications like semaglutide or tirzepatide lose some lean mass along with fat, typically about 2025% of total weight loss when diet and strength training are not optimized

The underlying mechanism of this phenomenon was down-regulation of ACAT1 and CD36 and ABCA1 up-regulation

GLP-1 receptor agonists and cardiovascular disease: drug-specific or class effects

Always verify that any supplier provides certificates of analysis and third-party testing documentation before purchasing

But thanks to getting 1 mg of semaglutide per week, they successfully lost 40 pounds after four months, claiming that the drug changed their life for the better in so many ways